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Table 1 Lessons learned

From: An initiative of cooperation in Zika virus research: the experience of the ZIKABRA study in Brazil

Topic Challenges Proposed solutions
Ethical evaluation in local and international partner institutions Different times for ethical evaluation of the study in the different national and international ethical instances Harmonize the CEP/CONEP System for urgent ethical evaluation in the different instances, respecting the Good Research Practices, in the national context.
Multi-institutional funding Raising and making public funds available quickly by partner institutions Fine-tune regulatory and decision-making processes at partner institutions and make funds available on an urgent basis.
Technology availability Standardization of diagnostic tests throughout the study execution period Promote the sustainability and continuity of technological innovation development activities, training of high-level human resources.
Formalization of operational instruments Sharing of institutional and individual responsibilities among the different actors Expedite the drafting and harmonization of the basic text of the agreement among the parties.